Small intestinal bacterial overgrowth
100% of patients eradicated SIBO
Backed by Science. Built for Patients.
Clinical Evidence
At mBIOTA Labs, we create clinically proven medical foods for patients with GI disorders - combining scientific rigor with empathy and respect for the patient experience.
Peer-reviewed outcomes
Established Clinical Protocols
IBS
Irritable Bowel Syndrome
82% of patients experienced a significant reduction in at least one symptom
Crohn's disease
Inflammatory bowel disease
82% of patients induced remission
EoE
Eosinophilic esophagitis
88% of patients became asymptomatic after 4 weeks
IMO
Intestinal methanogen overgrowth
63% of patients eradicated overgrowth
Partial small bowel obstruction
Cleared 2 obstructions without hospitalization or surgery
Rheumatoid arthritis
Performed similarly to steroid treatment in a controlled study
Pancreatitis
89% of patients experienced reduced pain
SIBO
83% of patients normalized their lactulose breath test after 14-day elemental diet.
Rezaie et al., "Effect, Tolerability, and Safety of Exclusive Palatable Elemental Diet in Patients With Intestinal Microbial Overgrowth," Clinical Gastroenterology and Hepatology (2025)
80% of patients normalized their lactulose breath test after 14-day elemental diet.
Pimentel et al., "A 14-Day Elemental Diet Is Highly Effective in Normalizing the Lactulose Breath Test," Digestive Diseases and Sciences (2004)
IBS
73% of IBS patients experienced a meaningful reduction in abdominal pain, according to FDA-aligned guidelines.
Rezaie et al., "Abdominal Pain Response to a Two-Week Exclusive Palatable Elemental Diet in Irritable Bowel Syndrome: Post Hoc Analysis of a Prospective Trial," Gastroenterology (2026)
Crohn's disease
89% of patients achieved remission with elemental diet as primary treatment of acute disease, comparable efficacy to the steroid group.
O'Morain et al., "Elemental Diet as Primary Treatment of Acute Crohn's Disease," British Medical Journal (1984)
Patients following a half elemental diet had a lower relapse rate compared to those on a free diet (34.6% vs 64%).
Takagi et al., "Effectiveness of a Half Elemental Diet as Maintenance Therapy for Crohn's Disease," Alimentary Pharmacology & Therapeutics (2006)
Combining elemental diet with infliximab resulted in a superior remission rate in patients during dose escalation.
Hisamatsu et al., "Effect of Elemental Diet Combined With Infliximab Dose Escalation in Crohn's Disease," Intestinal Research (2018)
71% entered clinical remission and endoscopic healing seen in both terminal ileum and large bowel.
Yamamoto et al., "Impact of Elemental Diet on Mucosal Inflammation in Patients With Active Crohn's Disease," Inflammatory Bowel Diseases (2005)
EoE
Full mucosal healing and resolution of symptoms achieved by adding a 2 week course of the elemental diet to duplimab regimen.
Pirvaram et al., "Novel Strategy for Deep Remission in EoE: Combining Dupilumab With Palatable Elemental Diet," American Journal of Gastroenterology (2025)
In a meta-analysis of 33 studies, elemental diets were found to be effective for 90.8% of cases.
Arias et al., "Efficacy of Dietary Interventions for Inducing Histologic Remission in Patients With Eosinophilic Esophagitis," Gastroenterology (2014)
Elemental diet significantly decreased inflammation and improved symptom scores in adult EoE patients with 88% of patients becoming asymptomatic.
Warners et al., "Elemental Diet Decreases Inflammation and Improves Symptoms in Adult Eosinophilic Esophagitis Patients," Alimentary Pharmacology & Therapeutics (2017)
72% of adult EoE patients achieved histologic response with elemental diet over 4 weeks.
Peterson et al., "Elemental Diet Induces Histologic Response in Adult Eosinophilic Esophagitis," American Journal of Gastroenterology (2013)
IMO
63% of IMO patients eradicated methane overgrowth with exclusive palatable elemental diet.
Rezaie et al., "Effect, Tolerability, and Safety of Exclusive Palatable Elemental Diet in Patients With Intestinal Microbial Overgrowth," Clinical Gastroenterology and Hepatology (2025)
Partial small bowel obstruction
2 partial small bowel obstructions resolved completely in an outpatient setting — no hospitalization or surgery required.
Mehravar et al., "Outpatient Management of Partial Small Bowel Obstruction Using an Oral Palatable Elemental Diet," Digestive Diseases and Sciences (2025)
Rheumatoid arthritis
Elemental diet performed similarly to steroid treatment (oral prednisolone).
Podas et al., "Is Rheumatoid Arthritis a Disease That Starts in the Intestine?" Postgraduate Medical Journal (2007)
Pancreatitis
89% of chronic pancreatitis patients experienced significantly reduced abdominal pain with low-fat elemental diet.
Ikeura et al., "Beneficial Effect of Low-Fat Elemental Diet Therapy on Pain in Chronic Pancreatitis," International Journal of Chronic Diseases (2014)
Oral elemental diet reduced pain and improved nutritional indices.
Kataoka et al., "Effects of Oral Ingestion of the Elemental Diet in Patients With Painful Chronic Pancreatitis in the Real-Life Setting in Japan," Pancreas (2014)
Looking for more of the science behind mBIOTA?
Explore our Clinical Evidence Library for published studies and supporting research.
2023 Prospective Clinical Study, as published by:
Clinical Gastroenterology and Hepatology
Effect, Tolerability, and Safety of Exclusive Palatable Elemental Diet in Patients with Intestinal Microbial Overgrowth
Our 2023 clinical trial of a 2-week course of mBIOTA in SIBO and IMO patients. The mBIOTA Elemental diet was tolerated by 100% of patients, eradicated overgrowth in 73% of patients overall and provided adequate relief from symptoms in 83% of patients.
Clinically Proven for SIBO and IMO¹
In a Cedars-Sinai clinical study, the mBIOTA Elemental diet eradicated SIBO in 83% of patients.
A 2023 clinical trial at Cedars-Sinai in Los Angeles evaluated the mBIOTA Elemental Diet and demonstrated consistent eradication outcomes across patients with SIBO, IMO, or both.
Clinical Eradication Rates by Patient Cohort
Based on normalization of patient’s lactulose breath test after day 14 of exclusive elemental diet.
These findings support hundreds of other clinical studies (across five decades) that have also found that elemental diets can relieve symptoms of GI conditions like IMO and SIBO.²
Clinical Results
Participants reported up to an 82% reduction in 12 common GI symptoms.
Over the past 50 years, hundreds of clinical studies have shown that Elemental Diets help reduce symptoms of chronic GI conditions, including IBS and SIBO.²
In the 2023 clinical trial at Cedars-Sinai in Los Angeles, 83% of patients who completed two weeks of an exclusive elemental diet reported symptom relief that continued to improve even two weeks after diet completion.
Symptom Reduction after mBIOTA Elemental
Published Research Using Elemental Diets
Clinical Gastroenterology and Hepatology
Effect, Tolerability, and Safety of Exclusive mBIOTA Elemental Diet in Patients with Intestinal Microbial Overgrowth
Digestive Diseases and Sciences
Elemental Diet as a Therapeutic Modality: A Comprehensive Review
American College of Gastroenterology 2025
mBIOTA Elemental Diet Achieves Deep Remission in Dupilumab-Responsive EoE
Digestive Diseases & Sciences
Comparing Elemental Diet and Steroid Treatment in Crohn's Disease
Digestive Diseases & Sciences
mBIOTA Elemental Leads to Successful Outpatient Management of Partial Small Bowel Obstruction
American College of Gastroenterology 2025
mBIOTA Elemental Diet Does Not Promote Fungal Overgrowth and Reduce Candida
American College of Gastroenterology 2025
mBIOTA Elemental Diet Enables Outpatient Resolution of Partial Small Bowel Obstruction
American College of Gastroenterology 2025
Palatable mBIOTA Elemental Diet Reduces Visceral Fat Through Microbial and Hormonal Shifts
Digestive Disease Week 2025
Reduction of Methane Levels Correlates with Fecal Abundance of M. smithii
FNM 2024
Maintained Visceral and Total Body Fat Loss Following mBIOTA Elemental Diet
American College of Gastroenterology 2024
Achieving Organoleptic Acceptability with mBIOTA Elemental Formula
Digestive Disease Week 2024
Compliance, Safety, and Effect of Exclusive Palatable mBIOTA Elemental Diet in Microbial Overgrowth
