
Clinical Evidence Supporting the Use of Elemental Diet for GI Disorders
Millions of people worldwide suffer from gastrointestinal (GI) disorders that significantly impact their quality of life. Managing these conditions often involves navigating through a maze of restrictive diets, medications, and supplements, all while seeking a solution that offers relief.
Elemental diets have emerged as a clinically-proven option that provides a more natural and effective approach to managing GI distress.
In 2023, mBIOTA Elemental™ was used in the first prospective clinical trial of elemental diet for patients with SIBO and IMO.¹
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100% Patient Compliance
100% of trial participants made it to the end, finishing two weeks of exclusive mBIOTA Elemental™.
This has never been accomplished by any other elemental diet product in a clinical trial setting.
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83% Reported Significant Symptom Improvement
Of equal importance, beyond bacterial eradication, more than 80% experienced symptom improvement and reported feeling better.

Clinically Effective Symptom Reduction
Trial participants on average reported up to a 65% improvement in symptom severity across 12 common GI symptoms
When researchers followed up two weeks after the mBIOTA Elemental™ diet was completed, trial participants continued to show improved symptoms and sustained bacterial eradication.
Other Clinical Evidence of Elemental Diets
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Irritable Bowel Syndrome (IBS) and SIBO
Studies have shown that elemental diets can significantly reduce bacterial overgrowth in the small intestine. A landmark study published in the American Journal of Gastroenterology found that an elemental diet resulted in a 75% eradication rate of SIBO, providing substantial symptom relief for patients. Another retrospective study by Pimentel et al. found that an elemental diet normalized breath tests in 80% of patients with SIBO after 14 days.
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Crohn's Disease
Elemental diets have been validated as effective in inducing and maintaining remission in Crohn's disease. A study in the Journal of Parenteral and Enteral Nutrition concluded that elemental diets are comparably efficacious to corticosteroids in inducing remission, with a more favorable side effect profile.
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Eosinophilic Esophagitis (EoE)
Elemental diets are highly efficacious in managing EoE, an allergic inflammatory condition of the esophagus. Clinical trials have consistently shown significant symptomatic improvement and histologic remission in patients adhering to an elemental diet.
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Celiac Disease and Dermatitis Herpetiformis
In one study, patients who completed four weeks of exclusive elemental diet showed clinical improvement on par with a gluten free diet. Another study found that 100% of patients saw histologic improvement after two weeks of exclusive elemental diet, including alleviated skin rashes.
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Acute and Chronic Pancreatitis
Studies show that elemental diets are a viable alternative for patients with acute pancreatitis who cannot tolerate a regular diet and are not suitable for tube feeding.
For those with chronic pancreatitis, one prospective cohort study found that even a partial elemental diet supplementation resulted in complete pain resolution in 59% of patients, and pain improvement in 29%.
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Other GI Disorders
Elemental diets have also proven effective in managing irritable bowel syndrome (IBS), short bowel syndrome, specific food allergies, Eosinophilic Gastritis/Gastroenteritis (EGID), Intestinal Lymphangiectasia, Bile Acid Diarrhea, and prevention of Chemoradiation-Induced Oral Mucositis. The elemental diet mitigates inflammation, promotes mucosal healing, and enhances overall digestive health.
Better Taste. Better Results.
mBIOTA Elemental™ diet is a clinically proven medical food designed for the dietary management of GI dysfunction. All ingredients are in their simplest "elemental" form to aid digestion and our easily drinkable flavors reduce the chance of diet fatigue.
Better Taste. Better Results.
A truly palatable Elemental Diet is finally here.